NEURO
Uraemic polyneuropathy / myopathy
RESP
Volume overload pulmonary oedema
CVS
Volume overload hypertension
Atherosclerosis
Uraemic pericarditis
RENAL
Oliguria / anuria
Calcium disturbances
HyperPO4
Hyperkalaemia
Hypotonic hyponatraemia (water-wasting, salt-wasting)
Urea increases (decreased glomerular clearance)
Mixed HAGMA and NAGMA (loss of both Cl- excretion and excretion of anions like PO4 and SO4)
GIT
Decreased GI motility
GI bleeding
May be protein-restricted
HAEM
EPO-deficiency anaemia
Uraemic platelet dysfunction
TPO-deficiency thrombocytopaenia
IMMUNOLOGY
Increased risk of infections
PHARMACOLOGY
Decreased clearance of renally excreted drugs
Decreased protein binding if protein-wasting \(\to\) hypoalbuminaemia